Up + Heavy Grapple is almost always a Brainbuster (Vertical Suplex) of some sort. I use it on every edit, mostly because they're fairly reliable for outside dive setups. My lucha edits either use the Uproot Brainbuster or the Jumping Brainbuster as the animation looks like they're putting a lot of energy into lifting the opponent up. This unfortunately looks kind of silly when they lift larger opponents, but I'd rather it be reliable than them having nothing at all to set up those spots. A lot of my edits have outside dives too, even the larger ones - in the case of the latter, they're more rare. For many of my smaller edits they use them often, but they don't always happen.
If an edit has a reliable front grapple finisher, I'll put it in Down + Heavy Grapple slot. If it's a rare finisher from front grapple, I'll put it in the SML + MED category.
Here's what my Jessica Shields' edit Front Grapples look like:
The Dinosaur Buster (Red, White, and Blue Thunder Bomb) is what I've got marked as her F move, it's also intended to be her rare finisher. She finishes opponents with the Screw Slam followed by a pinfall, or the Spinning Backbreaker followed by a pinfall, or the Kneebreaker from Rear Grapples followed by the Ankle Lock. I've set it up this way so that she has reliable, but varied ways of finishing a match.